Application of zebrafish to safety evaluation in drug discovery
نویسندگان
چکیده
منابع مشابه
Zebrafish: from disease modeling to drug discovery.
The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding to include human disease. Zebrafish models based on known disease mechanisms have been developed in several therapeutic areas, including blood diseases, diabetes, muscular dystrophy, neurodegenerative disease, angiogenesis and lipid metabolism. This review summarizes recent progress in disease model...
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چکیده: یکی از دوره های مهم تاریخی ایران به لحاظ تأمین استقلال ملی مذهبی و حتی تأثیر آن بر فرهنگ و مذهب ایرانیان، دوره صفویه است. رسمیت دادن و رواج مذهب شیعه توسط شاه اسماعیل اول، یکی از مهمترین اقدامات این دولت محسوب می شود. بنابراین برای اجرای این سیاست، وی منصب صدارت را به عنوان منصبی مذهبی- حکو متی ایجاد کرد .این منصب از دوره ی تیموریان ایجاد شده بود ولی در اواخر این دوره اهمیت بیشتری یافت...
15 صفحه اولThe Zebrafish: Swimming to the Forefront of Drug Discovery
The increasing cost of bringing new drugs to the market is a driving force for the exploration of new technologies that allow high-content screening and earlier decisionmaking and prioritisation in drug discovery. As a vertebrate model organism highly relevant to human development and disease, the zebrafish has rapidly risen to a position of prominence in academic research laboratories – a deve...
متن کامل[Research and development of combinatorial bioengineering using zebrafish and its application on drug discovery].
The main challenge of the post-genomic era is to functionally characterize genes identified by the genome sequencing projects. Model organisms, including zebrafish (Danio rerio), are indispensable for this demanding task. Zebrafish has recently been successfully incorporated into large-scale genetic screens due to the optical clarity of the embryos and their accessibility to various experimenta...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 2020
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.2020-0021